tccc3197 NSC668394-Ezrin Inhibitor

Ezrin, an ezrin/radixin/moesin (ERM) family member, is evolutionarily conserved both structurally and functionally.By regulating membrane-cytoskeleton complexes, ezrin has key roles in normal cellular processes such as maintenance of membrane dynamics, survival, adhesion, motility, cytokinesis, phagocytosis and integration of membrane transport with signaling pathways. Ezrin function is actively regulated by its conformational changes . Ezrin exists in an inactive conformation, in which the membrane and actin-binding sites are masked by intramolecular interaction of the N-terminal and C-terminal domains. In its active open conformation, ezrin functions as a crosslinker between the plasma membrane and cortical cytoskeleton.



High expression of ezrin correlates with poor prognosis and metastasis in osteosarcoma.