tcba10117 IMPA1 Polyclonal Antibody

Western blot analysis of extracts of various cell lines, using IMPA1 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.Immunohistochemistry of paraffin-embedded rat testis using IMPA1 antibody at dilution of 1:100 (40x lens).Immunohistochemistry of paraffin-embedded rat kidney using IMPA1 antibody at dilution of 1:100 (40x lens).Immunohistochemistry of paraffin-embedded human lung cancer using IMPA1 antibody at dilution of 1:100 (40x lens).Immunohistochemistry of paraffin-embedded human liver cancer using IMPA1 antibody at dilution of 1:100 (40x lens).Immunohistochemistry of paraffin-embedded human colon using IMPA1 antibody at dilution of 1:100 (40x lens).Immunohistochemistry of paraffin-embedded human breast cancer using IMPA1 antibody at dilution of 1:100 (40x lens).Immunohistochemistry of paraffin-embedded human stomach using IMPA1 antibody at dilution of 1:100 (40x lens).Immunohistochemistry of paraffin-embedded mouse testis using IMPA1 antibody at dilution of 1:100 (40x lens).Immunohistochemistry of paraffin-embedded mouse kidney using IMPA1 antibody at dilution of 1:100 (40x lens).Immunofluorescence analysis of A549 cells using IMPA1 antibody. Blue: DAPI for nuclear staining.
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Product Description

This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.

Information

ApplicationWB, IHC, IF
Research AreaNeuroscience, Cardiovascular, Cell Biology, Metabolism, Lipid Metabolism pathway,
Species ReactivityHuman, Mouse, Rat
Host SpeciesRabbit
IsotypeIgG

Specifications

FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended DilutionWB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:10 - 1:100

Misc Information

Storage InstructionStore at -20℃. Avoid freeze / thaw cycles.
Alternative NamesIMP;IMPA;MRT59
SwissProtP29218
Gene ID3612 (human);
Calculated Molecular Weight21kDa/30kDa/36kDa
PurificationAffinity purification
Cellular LocationCytoplasm,
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