Product Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
Information
ApplicationWB, IHC, IF, FC
Research AreaCancer, Cardiovascular, Cell Biology, Metabolism, Lipid Metabolism pathway,
Species ReactivityHuman, Mouse, Rat
Host SpeciesRabbit
IsotypeIgG
Specifications
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, pH7.3.
Recommended DilutionWB 1:500 - 1:1000
IHC 1:20 - 1:50
IF 1:20 - 1:100
FC 1:20 - 1:50
Misc Information
Storage InstructionStore at 4℃. Avoid freeze / thaw cycles.
Alternative NamesCP33;CP34;CYP3A;CYP3A3;CYPIIIA3;CYPIIIA4;HLP;NF-25;P450C3;P450PCN1
Calculated Molecular Weight57kDa
PurificationAffinity purification
Cellular LocationEndoplasmic reticulum membrane,Microsome membrane,Single-pass membrane protein,