Product Description
This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Information
Species ReactivityHuman, Mouse, Rat
Cross reactivityHuman, Mouse, Rat
Host SpeciesRabbit
Immunogen / Amino acidsRecombinant fusion protein containing a sequence corresponding to amino acids
1686-1785 of human FLNB (NP_001157789.1).
IsotypeIgG
Specifications
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Tested ApplicationELISA,WB,IHC-P,IF/ICC
Recommended DilutionWB 1:500 - 1:1000
IHC-P 1:50 - 1:100
IF/ICC 1:20 - 1:100
SourceRabbit
Misc Information
Storage InstructionStore at -20℃. Avoid freeze / thaw cycles.
Alternative NamesAOI; FH1; SCT; TAP; LRS1; TABP; FLN-B; FLN1L; ABP-278; ABP-280; FLNB
Calculated Molecular Weight278kDa
Observed Molecular Weight298kDa
PurificationAffinity purification
Cellular LocationCytoplasm,Z line,cell cortex,cytoskeleton,myofibril,sarcomere,