Product Description
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Information
ApplicationWB, IHC, IF, IP, ChIP
Research AreaCancer, Stem cells, Wnt pathway, Apoptosis, Cardiovascular, Developmental Biology, Cell Biology, Metabolism, NF-κB pathway, Lipid Metabolism pathway,
Species ReactivityHuman, Mouse, Rat
Host SpeciesRabbit
IsotypeIgG
Specifications
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended DilutionWB 1:500 - 1:2000
IHC 1:50 - 1:100
IF 1:50 - 1:200
IP 1:50 - 1:200
ChIP 1:20 - 1:100
Misc Information
Storage InstructionStore at -20℃. Avoid freeze / thaw cycles.
Alternative NamesHD3;RPD3;RPD3-2
Calculated Molecular Weight48kDa/49kDa
PurificationAffinity purification
Cellular LocationCytoplasm,Nucleus,cytosol,