Product Description
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.
Information
ApplicationWB, IHC, IF, IP
Research AreaCancer, Stem cells, Cell cycle, Wnt pathway, Neuroscience, Cardiovascular, Developmental Biology, Cell Biology, NF-κB pathway, Neurodegeneration, Cell Cycle, Epigenetics,
Species ReactivityHuman, Mouse, Rat, Monkey
Host SpeciesRabbit
IsotypeIgG
Specifications
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended DilutionWB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:100
IP 1:50 - 1:200
Misc Information
Storage InstructionStore at -20℃. Avoid freeze / thaw cycles.
Alternative NamesHD2;RPD3;YAF1
Calculated Molecular Weight51kDa/55kDa
PurificationAffinity purification
Cellular LocationCytoplasm,Nucleus,