tcsc8217 AZD1390

AZD1390 is an ATM inhibitor.

IC50 & Target: ATM^[1]

In Vivo: Median survival of mice treated with AZD1390 and radiation are significantly longer than untreated control mice (p=0.001). No overt signs of treatment toxicity are observed with small animal radiation research platform (SARRP) contrary to wholehead irradiated mice that seem to develop mucositis and difficulties drinking and eating at doses >10 Gy in combination with AZD1390^[2].