tcsc7605 [Sar9,Met (O2) 11]-Substance P

[Sar9,Met(O2)11]-Substance P is a tachykinin NK₁ receptor selective agonist.

IC50 & Target: NK₁ receptor^[1]

In Vitro: [Sar9,Met(O2)11]-Substance P and septide (10-100 pmol per rat, i.c.v.) are equipotent in increasing mean arterial blood pressure (MAP) and heart rate (HR), yet they have dissimilar time-course. Both agonists increase dose-dependently face washing and sniffing while [Sar9,Met(O2)11]-Substance P is the sole to produce grooming^[1].