tcsc7385 COX / 5-LO-IN-1

COX/5-LO-IN-1 is an inhibitor of cylooxygenase and 5-lipoxygenase, used for the research of inflammatory and allergic disease states.

In Vitro: COX/5-LO-IN-1 reduces the biosynthesis of leukotrienes B4, C4, D4, and E4 and cyclooxygenase products such as prostaglandins and thromboxane and are useful in the treatment of inflammatory and allergic disease states^[1]. COX/5-LO-IN-1 shows inhibitory activities against 5-lipoxygenase, with IC₅₀ of 0.2 μM in human whole blood^[2].