tcsc7094 Neurokinin A (4-10)

Neurokinin A (4-10) is a tachykinin NK₂ receptor agonist. Sequence: Asp-Ser-Phe-Val-Gly-Leu-Met-NH2.

IC50 & Target: NK₂ receptor^[1]

In Vitro: Neurokinin A (NKA) and its truncated form NKA(4-10) are potent spasmogens of human colon circular muscle, an action mediated exclusively via tachykinin NK₂ receptors. A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) is performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK₂ receptor in human colon circular muscle. A high density of NK₂ receptors has been demonstrated in this tissue, using in vitro autoradiography and radioligand binding^[1].