tcsc6716 RWJ 63556

RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities.

In Vitro: RWJ 63556 is a potent inhibitor of leukocyte influx over a period of 24 hr and maintains its in vitro profile on eicosanoids^[1].

In Vivo: RWJ 63556 (1 mg/kg, i.v.) significantly inhibits the development of SP-induced oedema^[2].