tcsc6668 Irindalone

Irindalone is a novel serotonin 5-HT₂ antagonist.

IC50 & Target: 5-HT₂^[1]

In Vitro: Irindalone causes a concentration-related inhibition of serotonin-induced contractions and shifts the serotonin curve to the right. Irindalone is more potent in inhibiting the serotonin-induced contractions. Irindalone has a similar profile in vitro, with a high affinity for serotonin 5-HT₂ receptors and about a 10 times lower affinity for α₁-adrenoceptors^[1].

In Vivo: Irindalone dose dependently lowers the blood pressure in spontaneously hypertensive rats (SHR) and renal hypertensive dogs^[1].