tcsc6383 SUN11602

SUN11602 is a novel aniline compound with basic fibroblast growth factor-like activity.

In Vitro: SUN11602 prevents glutamate-induced neuronal death in primary cultures of rat cerebrocortical neurons. SUN11602 increases the levels of CALB1 gene expression in cerebrocortical neurons^[1]. SUN11602 exerts protective effects on hippocampal neurons through activation of FGFR1 and increases CalB expression^[2]. SUN11602 promotes neurite outgrowth of primarily cultured rat hippocampal neurons^[3].

In Vivo: In WT mice, SUN11602 increases the levels of newly synthesized Calb in cerebrocortical neurons and suppresses the glutamate-induced rise in intracellular Ca²⁺. This Ca²⁺-capturing ability of Calb allows the neurons to survive severe toxic conditions of glutamate^[1]. Oral administration of SUN11602 at the midpoint of Aβ1-40 and ibotenate injections attenuate short-term memory impairment in the Y-maze test, as well as spatial learning deficits in the water maze task. In addition, the SUN11602 treatment inhibits the increase of peripheral-type benzodiazepine-binding sites (PTBBS),which are a marker for gliosis^[3].