tcsc5889 AZD0156

AZD0156 is an oral, potent and selective ATM inhibitor with an IC₅₀ of 0.58 nM.

In Vitro: AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells^[1].