tcsc5160 Tolmetin (sodium dihydrate)

Tolmetin sodium dihydrate is a non-steroidal antiinflammatory agent, and acts as a non-selective COX inhibitor.

IC50 & Target: COX^[1]

In Vitro: Tolmetin sodium dihydrate is a non-steroidal antiinflammatory agent. Tolmetin (0-100 μM) shows no effect on osteoblast growth^[2]. Tolmetin (0.25 mM) dose not attenuate lipid peroxidation in rat brain homogenate. Tolmetin (0.25, 0.5, 0.75, 1 mM) shows radical scavenging properties but without superoxide anion generation in rat brain homogenat^[3].

In Vivo: Tolmetin (100 mg/kg) causes gastric lesions, and shows maximal ulcerogenic effect 4 h after the single dose, while potently decreases after 3 and 14 days of repeated administration. Tolmetin produces obvious endothelial damage and inflammatory cell infiltration^[1]. Tolmetin (5 mg/kg, i.p., twice a day for 5 days) has no effect on n NMDA receptor binding in rats^[3].