tcsc4953 PU-WS13

PU-WS13 is a selective Grp94 inhibitor, with an EC₅₀ of 0.22 μM.

IC50 & Target: EC50: 0.22 μM (Grp94), 7.3 μM (Trap-1), 27.3 μM (Hsp90α), 41.8 μM (Hsp90β)^[1]

In Vitro: PU-WS13 is a Grp94 inhibitor, with an EC₅₀ of 0.22 μM. PU-WS13 also slightly suppresses Hsp90α, Hsp90β and Trap-1, with EC₅₀s of 27.3, 41.8 and 7.3 μM, respectively. PU-WS13 (2.5-20 μM) shows no toxicity on two nonmalignant cell lines. PU-WS13 (15 μM) disrupts the circular architecture of HER2 at the plasma membrane of SKBr3 cells mediated through Grp94. PU-WS13 inhibits Grp94, and the inhibition induces apoptosis in and reduce the viability of HER2 overexpressing breast cancer cells^[1].