tcsc3614 Bay-K-8644 ( (R) - (+) -)

Bay-K-8644 (R)-(+)- is a calcium channel inhibitor. Bay-K-8644 (R)-(+)- inhibits Ba²⁺ currents (I_Ba) (IC₅₀=975 nM).

IC50 & Target: IC50: 975 nM (I_Ba)^[1]

In Vitro: (±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca²⁺ channel agonist. Each optical isomer possesses opposite effects on I_Ba, Bay-K-8644 (R)-(+)- as an antagonist and S(-)-Bay K 8644 as an agonist. Bay-K-8644 (R)-(+)- inhibits Ba²⁺ currents (I_Ba) (IC₅₀=975 nM). When Bay-K-8644 (R)-(+)- (0.5 μM) is applied, I_Ba is suppressed to 71±10% of control. In the presence of Bay-K-8644 (R)-(+)- (0.5 μM), additional application of forskolin and sodium nitroprusside (SNP) further inhibits I_Ba^[1]. Bay-K-8644 (R)-(+)- is a calcium channel inhibitor^[2].