tcsc3428 6H05 (trifluoroacetate)

6H05 trifluoroacetate is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C).

IC50 value:

Target: K-Ras G12C

6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras [1]. 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors [2].