tcsc2977 Fotemustine

Fotemustine is a DNA-alkylating agent, with antitumor activity.

IC50 & Target: DNA Alkylator^[1]

In Vitro: Fotemustine is a DNA-alkylating agent. Fotemustine (800 μM) decreases GSH and intracellular GSSG levels but increases the extracellular GSSG-levels rapidly in isolated rat hepatocytes^[1]. Fotemustine shows inhibitory effect on several tumor cell lines, with IC₅₀s ranging form 0.05 to 0.18 mM^[2].