tcsc2175 Ketoprofen

Ketoprofen is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC₅₀s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively.

IC50 & Target: IC50: 2 nM (COX-1, in human blood monocytes), 26 nM (COX-2, in human blood monocytes)^[1]

In Vitro: Ketoprofen (Compound 2) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC₅₀s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively^[1].

In Vivo: Ketoprofen (0.32-10 mg/kg, s.c) dose-dependently inhibits acid-induced depression of nesting (IC₅₀, 2.05 mg/kg), and reverses CFA-induced such depression at 0.1-10 mg/kg, with an IC₅₀ of 0.18 mg/kg in mice^[2].