Product Description
Etoposide is a chemotherapy medication used for the treatments of a number of types of cancer. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA.
In Vitro: Etoposide is capable of causing cytotoxicity on pancreatic β-cells by inducing apoptosis through the JNK/ERK-mediated GSK-3 downstream-triggered mitochondria-dependent signaling pathway in RIN-m5F cells[1]. Etoposide and Bevacizumab significantly abolish P1 sphere-forming ability, an effect associated with apoptosis of this subset of cells[2].
In Vivo: Etoposide (50 μM) and Bevacizumab-treated hypoxic cells injected intravenously into immunodeficient mice reveals a reduced capacity to induce lung colonies, which also appear with a longer latency period[2]. Etoposide (10 mg/kg/day, i.v.) with ifosfamide and carboplatin, reduces the tumor volume in the hepatoblastoma cell injected NMRI nude mice[3].
Information
CAS No33419-42-0
FormulaC29H32O13
Clinical Informationclinicalinformation
PathwayAnti-infection
Apoptosis
Autophagy
Cell Cycle/DNA Damage
TargetAntibiotic
Apoptosis
Autophagy
Bacterial
Mitophagy
Topoisomerase
Specifications
FormWhite to off-white (Solid)
Purity / Grade99.67%
SolubilityDMSO : ≥ 39 mg/mL (66.26 mM)
SmilesO=C1OC[C@]2([H])[C@H](O[C@H]3[C@@H]([C@H]([C@@H]4O[C@H](C)OC[C@H]4O3)O)O)C5=C(C=C6OCOC6=C5)[C@@H](C7=CC(OC)=C(O)C(O
C)=C7)[C@]21[H]
Misc Information
Storage Instruction2-8°C, protect from light
Alternative NamesVP-16;VP-16-213;Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[[4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphen
yl)-, (5R,5aR,8aR,9S)-
Observed Molecular Weight588.56
NotesFormulation: 5% DMSO+40% PEG 300+5% Tween 80+water
15 mg/mL
References[1]. Lee KI, et al. Etoposide induces pancreatic β-cells cytotoxicity via the JNK/ERK/GSK-3 signaling-mediated mitochondria-dependent apoptosis pathway.
Toxicol In Vitro. 2016 Jul 26. pii: S0887-2333(16)30147-3.
[2]. Calvani M, det al. Etoposide-Anti-Human VEGF a new strategy against human melanoma cells expressing stem-like traits. Oncotarget. 2016 Jun 9. doi:
10.18632/oncotarget.9939.
[3]. Fuchs, J., et al. Comparative activity of NSC 119875, NSC 109724, NSC 123127, NSC 241240, and etoposide in heterotransplanted hepatoblastoma.
Cancer, 1998. 83(11): p. 2400-7.
[4]. Hande KR, et al. The Importance of Drug Scheduling in Cancer Chemotherapy: Etoposide as an Example. Oncologist. 1996;1(4):234-239.
[5]. Cui D, et al. FBXW7 Confers Radiation Survival by Targeting p53 for Degradation.Cell Rep. 2020 Jan 14;30(2):497-509.e4.