tcsc1748 Deltarasin (hydrochloride)

Deltarasin hydrochloride is an inhibitor of KRAS-PDEδinteraction with K_d of 38 nM for binding to purified PDEδ.

IC50 & Target: Kd: 38 nM (PDEδ)

In Vitro: In liver cells, deltarasin inhibits the interaction of RAS with PDEδ with K_D of 41 nM. Inhibition of PDEδ-KRAS interaction by deltarasin suppresses proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS^[1].

In Vivo: Deltarasin (10 mg/kg, i.p.) impairs dose-dependent tumor growth in nude mice bearing subcutaneous human Panc-Tu-I tumour cell xenografts^[1].