tcsc1309 DMA

DMA is a fluorescent compound (λ_ex=340 nm, λ_em=478 nm).

IC50 & Target: IC50: 3.4 μM (HeLa cell), 5.3 μM (MCF7 cell)^[1]

In Vitro: The newly synthesized bisbenzimidazole derivatives DMA (6c) is evaluated for their cytotoxicity against human tumor cell lines, which are cervix carcinoma cell line (HeLa), breast carcinoma cell line (MCF7) and brain glioma cell line (U87) in comparison to Hoechst. In case of MCF7, the IC₅₀ is observed at 5.3 μM for DMA. The IC₅₀ determined in the case of HeLa is 3.4 μM for DMA^[1].