tcsc1227 Voriconazole

Voriconazole(UK-109496) is a second-generation triazole antifungal used to treat serious fungal infections.

IC50 Value:

Target: Antifungal

Voriconazole displays potent activity against Candida, Cryptococcus and Aspergillus species. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes.