tcsc0850 ML-7 (hydrochloride)

ML-7 hydrochloride is a naphthalene sulphonamide derivative, potently inhibits MLCK (IC₅₀=300 nM) and TRPC6 channel (IC₅₀>10 μM).

IC50 & Target: IC50: 300 nM (MLCK)^[1]

In Vitro: ML-7 hydrochloride inhibits rabbit portal vein α1-adrenoceptor NSCC with IC₅₀ of 0.8 μM^[1]. The myosin light chain kinase (MLCK) inhibitor ML-7 hydrochloride (3 μ M and 10 μM) also attenuates the Dexmedetomidine (DMT)-induced contraction (p<0.05 versus control)^[2].

In Vivo: In sham operated animals Evans Blue extravasation is not different between ML-7 hydrochloride and vehicle group (sham+vehicle: 0.26±0.02 OD/g; sham+ML-7: 0.26±0.02 OD/g). After CCI inhibition of MLCK with ML-7 results in a significant lower amount of intracerebral Evans Blue compared to vehicle treated animals (CCI+vehicle: 0.42±0.04 OD/g; CCI+ML-7: 0.35±0.05 OD/g, p=0.048)^[3].