tcsc0748 A-803467

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Product Description

A 803467 is a selective Nav1.8 sodium channel blocker with an IC50 of 8 nM; over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7.

IC50 value: 8 nM

Target: Nav1.8 sodium channel

A 803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models.

Information

CAS No944261-79-4
FormulaC19H16ClNO4
Clinical Informationclinicalinformation
PathwayMembrane Transporter/Ion Channel
TargetSodium Channel

Specifications

Purity / Grade>98%
SolubilityDMSO : 50 mg/mL (139.75 mM; Need ultrasonic)
Smilessmiles

Misc Information

Observed Molecular Weight357.79
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