tcsc0680 MK-2894 (sodium salt)

MK-2894 sodium salt is a highly potent and selective second generation EP4 antagonist.

IC50 value:

Target: EP4

MK-2894 exhibits favorable pharmacokinetic profile in a number of preclinical species and potent anti-inflammatory activity in several animal models of pain/inflammation. MK-2894 also shows favorable GI tolerability profile in rats when compared to traditional NSAID indomethacin.