tcsc0374 Pentostatin

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Data sheet

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Product Description

Pentostatin is an irreversible inhibitor of adenosine deaminase with Ki of 2.5 pM.

IC50 & Target: Ki: 2.5 pM (adenosine deaminase)

In Vivo: In ECP and Pentostatin (4 mg/m2, i.v.) treatment, all dogs develop granulocytopenia with <500 granulocytes/μL from day 4. Thrombocytopenia (<20,000 platelets/μL) occurs from day 7 after HCT with nadirs of 3000 to 14000 platelets/μL[1]. Pentostatin (2 mg/kg) in combination with cordycepin (2 mg/kg) is 100% effective in the T. evansi-infected mice. There is an increase in levels of some biochemical parameters, especially on liver enzymes, which are accompanied by histological lesions in the liver and kidneys. Pentostatin individually has no curative effect on infected groups[2].

Information

CAS No53910-25-1
FormulaC11H16N4O4
Clinical Informationclinicalinformation
PathwayMetabolic Enzyme/Protease
TargetAdenosine Deaminase

Specifications

Purity / Grade>98%
SolubilityDMSO : ≥ 50 mg/mL (186.38 mM)
Smilessmiles

Misc Information

Alternative NamesCI-825;Deoxycoformycin
Observed Molecular Weight268.27
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