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BioChemicals
Pentostatin
tcsc0374
Pentostatin
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AVAILABLE SIZES
10mg
50mg
$
156.00
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ORDERING INFORMATION
International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807
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Western blot (WB)
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Product Description
Pentostatin is an irreversible inhibitor of
adenosine deaminase
with
K
i
of 2.5 pM.
IC50 & Target: Ki: 2.5 pM (adenosine deaminase)
In Vivo:
In ECP and Pentostatin (4 mg/m
2
, i.v.) treatment, all dogs develop granulocytopenia with <500 granulocytes/μL from day 4. Thrombocytopenia (<20,000 platelets/μL) occurs from day 7 after HCT with nadirs of 3000 to 14000 platelets/μL
[1]
. Pentostatin (2 mg/kg) in combination with cordycepin (2 mg/kg) is 100% effective in the T. evansi-infected mice. There is an increase in levels of some biochemical parameters, especially on liver enzymes, which are accompanied by histological lesions in the liver and kidneys. Pentostatin individually has no curative effect on infected groups
[2]
.
Information
CAS No
53910-25-1
Formula
C
11
H
16
N
4
O
4
Clinical Information
clinicalinformation
Pathway
Metabolic Enzyme/Protease
Target
Adenosine Deaminase
Specifications
Purity / Grade
>98%
Solubility
DMSO : ≥ 50 mg/mL (186.38 mM)
Smiles
smiles
Misc Information
Alternative Names
CI-825;Deoxycoformycin
Observed Molecular Weight
268.27
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