tcsc0362 R-1479

R-1479 is a specific inhibitor of HCV replication in the HCV subgenomic replicon system (IC₅₀=1.28 μM).



IC50 & Target: IC50: 1.28 μM (HCV replication)^[1]

In Vitro: R-1479 (R1479) inhibits HCV RNA replication with a mean IC₅₀ value of 1.28 μM when measured as dose-dependent reduction of Renillaluciferase activity after a 72 h incubation of proliferating replicon cells. R-1479 shows no effect on cell viability or proliferation of HCV replicon or Huh-7 cells at concentrations up to 2 mM^[1]. The most potent and non-cytotoxic derivative is R-1479 with an IC₅₀ of 1.28 μM in the HCV replicon system. The triphosphate of R-1479 is prepared and shown to be an inhibitor of RNA synthesis mediated by NS5B (IC₅₀=320 nM), the RNA polymerase encoded by HCV. R-1479 displays good activity in the replicon assay with no measurable cytotoxic or cytostatic effect^[2].