tcsc0047 GSK319347A

GSK319347A is a dual inhibitor of TBK1 and IKKε with IC₅₀s of 93 nM and 469 nM, respectively. GSK319347A also inhibits IKK2 with an IC₅₀ of 790 nM.

IC50 & Target: IC50: 93 nM (TBK1), 469 nM (IKKε)^[1]


IC50: 790 nM (IKK2)^[2]

In Vitro: GSK319347A (Compound 1) inhibits TBK1 enzyme with an IC₅₀ of 93 nM, which also translates into good cell potency (72 nM). Moreover, IKK-3 Inhibitor exhibits excellent selectivity against cell-cycle kinases CDK2 and AurB^[1]. IKK-3 Inhibitor (Compound 13) is a novel IκB kinase 2 (IKK2) inhibitor with an IC₅₀ of 790 nM^[2].