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Product Description
Solutol HS-15 is a permeability enhancer.
In Vitro: Solutol HS-15 is a permeability enhancer. A general decline in cell metabolic activity is seen for all three tested cell lines as the concentration of Solutol HS-15 solution is increased. Results demonstrate that Solutol HS-15 promotes the apical-to-basolateral translocation of a model protein (insulin) across Calu-3 monolayers when applied at 37°C. Furthermore there is no statistically significant increase in insulin permeability in the presence of Solutol HS-15, relative to the respective control, at 4°C. Solutol HS-15 treated cells show a statistically significant increase in permeability towards lower molecular weight permeants (5 to 22 kDa) and an absence of a statistically significant increase in permeability of proteins with larger molecular weight, namely albumin and IgG (P>0.05 relative to control)[1].
Information
CAS No61909-81-7
Formula(C2H4O)nC18H36O3
Clinical Informationclinicalinformation
PathwayOthers
TargetOthers
Specifications
Purity / Grade>98%
Solubility10 mM in DMSO
Smilessmiles
Misc Information
Observed Molecular Weight1000
related data
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