tcsc0040308 E-7386

E-7386 is an orally active CBP/beta-catenin modulator.

IC50 & Target: CBP/beta-catenin^[1]

In Vivo: E-7386 is an orally active CBP/beta-catenin modulator which can induce T cells infiltration into tumor and enhance antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model. E-7386 shows significant antitumor activity in Wnt1 model. Infiltration of T cells is limited in vehicle control group, but T cell infiltration into tumors is clearly observed in E-7386 treatment group^[1].