tcsc0039381 3,6-DMAD hydrochloride

3,6-DMAD hydrochloride is a inhibitor of the IRE1α-XBP1 pathway of the unfolded protein response.

IC50 & Target: IRE1α^[1]

In Vitro: 3,6-DMAD inhibits both IRE1α oligomerization and in vitro endoribonuclease (RNase) activity^[1].

In Vivo: Following three intraperitoneal administrations of 3,6-DMAD at a dose of 10 mg/kg every 12 hours, 3,6-DMAD significantly inhibits in vivo XBP1-luciferase activity assessed 3.5 days after the initial treatment. 3,6-DMAD-treatment significantly inhibits tumor xenograft growth^[1].