tcsc0035397 DDR1-IN-2

DDR1-IN-2 is a potent inhibitor of discoidin domain receptor 1 (DDR1), with an IC₅₀ of 13.1 nM, and also less potently inhibits DDR2, with an IC₅₀ of 203 nM.

IC50 & Target: IC50: 13.1 nM (DDR1), 203 nM (DDR2), 414 nM (Bcr-Abl), 2500 nM (c-Kit)^[1]

In Vitro: DDR1-IN-2 (compound 1) is a potent inhibitor of DDR1, with an IC₅₀ of 13.1 nM, and less potently inhibits DDR2, with an IC₅₀ of 203 nM. DDR1-IN-2 also shows inhibitory activities against Bcr-Abl and c-Kit, with IC₅₀s of 414 and 2500 nM, respectively^[1].