tcsc0035171 Parbendazole

Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC₅₀ of 8.79 nM, and exhibits a broad-spectrum anthelmintic activity.

IC50 & Target: EC50: 8.79 nM (tubulin)^[1]

In Vitro: Parbendazole is a tubulin destabilizer, with an EC₅₀ of 8.79 nM, and can induce DNA damage^[1]. Parbendazole (2-10 μM) inhibits the assembly of microtubules dose-dependently, with an IC₅₀ of 3 μM. Parbendazole (2-20 μM)-treated cells show an complete absence of microtubules in Vero cells^[2]. Parbendazole (up to 10 μM) inhibits the growth of CLd-AXE myxamoebae. Parbendazole (2-5 μM) potently inhibits tubulin purified from the wild-type myxamoebae^[3].