tcsc0031115 HIV-1 integrase inhibitor 4

HIV-1 integrase inhibitor 4 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC₅₀ of 3.7 nM.

IC50 & Target: IC50: 3.7 nM (INST)^[1]

In Vitro: HIV-1 integrase inhibitor 4 (compound 4f) is a HIV-1 integrase strand transfer (INST) inhibitor with an IC₅₀ of 3.7 nM. HIV-1 integrase inhibitor 4 shows potent activity against recombinant HIV IN in biochemical assays and good efficacy in assays done in cell culture against a broad panel of viral mutants carrying the major RAL and DTG IN resistance mutations^[1].