tcsc0030145 PF-9366

PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor, with an IC₅₀ of 420 nM and a K_d of 170 nM.

IC50 & Target: IC50: 420 nM (Mat2A)^[1]


Kd: 170 nM (Mat2A)^[1]

In Vitro: PF-9366 is a Mat2A inhibitor, with an IC₅₀ of 420 nM and a K_d of 170 nM. PF-9366 displays no substantial off-target activity in GPCRs, neurotransporters, phosphodiesterases, and ion channels. PF-9366 has inhibitory activity against Mat2A in cancer cells. PF-9366 inhibits cellular S-Adenosyl-L-methionine (SAM) production with an IC₅₀ of 1.2 μM in H520 lung carcinoma cells. PF-9366 is more potent in Huh-7 cells against SAM synthesis, with an IC₅₀ of 255 nM, and also suppresses the proliferation of cells with an IC₅₀ of 10 μM.