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BioChemicals
Kynurenic acid (sodium)
tcsc0028676
Kynurenic acid (sodium)
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AVAILABLE SIZES
100mg
$
86.00
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ORDERING INFORMATION
International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807
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Product Description
Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting
NMDA, glutamate, α7 nicotinic acetylcholine receptor
. Kynurenic acid is also a selective ligand of the
GPR35
receptor.
IC50 & Target: Target: GPR35
[1]
, NMDA, glutamate, glutamate, α7 nicotinic acetylcholine
[2]
In Vitro:
GPR35 functions as a receptor for the kynurenine pathway intermediate kynurenic acid. Kynurenic acid elicits calcium mobilization and inositol phosphate production in a GPR35-dependent manner in the presence of G
qi/o
chimeric G proteins. Kynurenic acid stimulates [
35
S]guanosine 5′-O-(3-thiotriphosphate) binding in GPR35-expressing cells, an effect abolished by pertussis toxin treatment. Kynurenic acid also induces the internalization of GPR35
[1]
. KYNA’s neuroinhibitory qualities and its neuroprotective and anticonvulsant effects are discovered using concentrations of the compound in the millimolar range. This, as well as the low affinity of KYNA at each of the three ionotropic glutamate receptors responsible for these effects [NMDA, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate], together with the realization that KYNA concentrations in the mammalian brain are in the sub-micromolar range, suggested that other receptors might serve as targets of endogenous Kynurenic acid. Kynurenic acid, with a shallower inhibition curve and non-competitively, antagonizes α7nAChRs on cultured hippocampal neurons with an IC
50
in the low micromolar range
[2]
.
In Vivo:
Kynurenic acid affects the activity of leukocytes in the peripheral blood of mice, although the lowest one (2.5 mg/L) has the most profound influence in contrast to the highest one (250 mg/L), which produces the weakest effect. The lowest Kynurenic acid dose stimulates the proliferative response of T lymphocytes (p<0.05), after 7 and 28 days of administering the acid to the animals
[3]
.
Information
CAS No
2439-02-3
Formula
C
10
H
7
NNaO
3
Clinical Information
clinicalinformation
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
iGluR
iGluR
Specifications
Purity / Grade
>98%
Solubility
H2O : < 0.1 mg/mL (insoluble)
Smiles
smiles
Misc Information
Observed Molecular Weight
212.16
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