tcsc0028514 OSS_128167

OSS_128167 is a selective SIRT6 inhibitor with IC₅₀s of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively.

IC50 & Target: IC50: 89 μM (SIRT6), 1578 μM (SIRT1), 751 μM (SIRT2)^[1]

In Vitro: OSS_128167 is a selective SIRT6 inhibitor with IC₅₀s of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 inhibits SIRT6 in the micromolar range, but shows promising selectivity, since its IC₅₀ value for SIRT6 is approximately 17 times lower compare to the IC₅₀ for SIRT1 and 9 times lower compare to SIRT2^[1]. OSS_128167 (200 μM) induces chemosensitization in primary multiple myeloma (MM) cells (NCI-H929), as well as in melphalan-resistant (LR-5) and doxorubicin-resistant (Dox40) MM cell lines^[2].