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BioChemicals
G-1
tcsc0027669
G-1
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AVAILABLE SIZES
1mg
5mg
10mg
$
71.00
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ORDERING INFORMATION
International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807
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Product Description
G-1 is a nonsteroidal, high-affinity and selective agonist of
GPR30
with a
K
i
of 11 nM.
IC50 & Target: Ki: 11 nM (GPR30)
[1]
In Vitro:
G-1 is a nonsteroidal, high-affinity and selective agonist of GPR30 with a K
i
of 11 nM
[1]
. Treatment with G-1 (10 μM and 100 μM) for 48 and 72 h significantly decreases cell proliferation (P<0.001). At 72 h, the IC
50
value for G-1 is calculated to be 20 μM. Treatment of A549 cells with G-1 at a concentration of 20 μM reveals a significant increase in apoptosis, consistent with its antiproliferative effect (P<0.001)
[2]
. Cell cycle analysis of H295R cells after 24 h of G-1 treatment demonstrates a cell cycle arrest in the G
2
phase. The presence of G-1 increases Bax expression while decreases Bcl-2
[3]
.
In Vivo:
The results at 14 days post-injury show that the Basso mouse scale (BMS) scores are significantly higher in the G-1 group compared with the other groups (P<0.05). The number of caspase-3-positive cells in the cross sections is counted, and G-1 group has fewer positive cells compare with the other groups (P<0.05), and there is no difference between the two groups (P>0.05)
[1]
. G-1 administration produces a statistically significant decrease in tumor volume from day 14 post treatment. Grafted tumors harvested after three-week treatment with G-1 show a significant decrease in tumor weight compare to vehicle treated animals
[3]
.
Information
CAS No
881639-98-1
Formula
C
21
H
18
BrNO
3
Clinical Information
clinicalinformation
Pathway
Others
Target
Estrogen Receptor/ERR
Specifications
Purity / Grade
>98%
Solubility
H2O : < 0.1 mg/mL (insoluble); DMSO : 50 mg/mL (121.28 mM; Need ultrasonic)
Smiles
smiles
Misc Information
Observed Molecular Weight
412.28
related data
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