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BioChemicals
GENZ-882706
tcsc0021628
GENZ-882706
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AVAILABLE SIZES
5mg
10mg
25mg
50mg
$
786.00
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ORDERING INFORMATION
International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807
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Western blot (WB)
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Product Description
GENZ-882706 is a potent colony stimulating factor-1 receptor (
CSF-1R
) Inhibitor extracted from patent WO 2017015267A1.
IC50 & Target: Target: CSF-1R
[1]
In Vitro:
Genz-882706 induces an increased level of proliferative activity on unstimulated cells 48 hours post treatment and the reason for this effect is unclear
[1]
.
In Vivo:
Daily treatment with Genz-882706 significantly reduces experimental autoimmune encephalomyelitis. Treatment with Genz-882706 in experimental autoimmune encephalomyelitis (EAE) mice results in significant decreases in MCP-1, IL-6, IL-Ιβ and IP-10 levels in spinal cord homogenates when compared to Vehicle treated animals. Treatment with Genz-882706 shows a significant increase in TNF-a levels in the spinal cord when compared to the vehicle treated group. Genz-882706 at both the 30 mg/kg and the 100 mg/kg dose significantly reduces the number of microglia and monocytes/macrophages in the brain and spinal cord compared to the vehicle and LPS controls. Treatment with Genz-882706 modestly reduces CD80 expression on monocytes/macrophages in the brain
[1]
.
Information
CAS No
2070864-35-4
Formula
C
26
H
25
N
5
O
3
Clinical Information
clinicalinformation
Pathway
Others
Target
Others
Specifications
Purity / Grade
>98%
Solubility
10 mM in DMSO
Smiles
smiles
Misc Information
Alternative Names
RA03546849
Observed Molecular Weight
455.51
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