tcsc0018427 MK-3328

MK-3328 is a β-Amyloid PET ligand, which exhibits high binding potency with an IC₅₀ of 10.5 nM.

IC50 & Target: IC50: 10.5 nM (β-Amyloid)^[1]

In Vitro: MK-3328 exhibits amyloid binding potency balanced with low levels of nonspecific binding^[1].

In Vivo: In vivo, [¹⁸F]MK-3328 demonstrates favorable kinetics, exhibiting high brain uptake and good washout in normal rhesus monkey positron emission tomography (PET) imaging studies^[1].