tcsc0018422 Org41841

Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC₅₀s of 0.2 and 7.7 μM, respectively.

IC50 & Target: EC50: 0.2 μM (LHCGR), 7.7 μM (TSHR)^[1]

In Vitro: Functional assays demonstrate that Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC₅₀s of 0.2 and 7.7 μM, respectively. Treatment of L570F with Org41841 reveals an improved EC₅₀ of 800 nM. M9 responds to Org41841 with an improved EC₅₀ of 2700 nM and a greatly improved efficacy for signaling to 99% of the maximal value observed for thyroid-stimulating hormone (TSH) stimulation of thyroid-stimulating hormone receptor (TSHR)^[1].