tcsc0018389 Antihistamine-1

Antihistamine-1 is a H1-antihistamine (K_i=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC₅₀s of 5.4 and 0.8 μM, respectively.

IC50 & Target: Ki: 6.9 nM (H1-antihistamine)^[1]


IC50: 5.4 μM (CYP2D6), 0.8 μM (hERG channel)^[1]

In Vitro: Antihistamine-1 (Compound 2) is a H1-antihistamine (K_i=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC₅₀s of 5.4 and 0.8 μM, respectively^[1].