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Product Description
Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively.
IC50 & Target: Ki: 6.9 nM (H1-antihistamine)[1]
IC50: 5.4 μM (CYP2D6), 0.8 μM (hERG channel)[1]
In Vitro: Antihistamine-1 (Compound 2) is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively[1].
Information
CAS No1186430-60-3
FormulaC23H24FN5
Clinical Informationclinicalinformation
PathwayImmunology/Inflammation GPCR/G Protein Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
