tcsc0002 MK 2206 (dihydrochloride)

Order Now

AVAILABLE SIZES

$189.00 ORDERING INFORMATION International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807

Data sheet

Download PDF Datasheet

Technical Inquries

Submit Review

Product Description

MK 2206 is an orally active allosteric Akt inhibitor with IC50s of 5, 12 and 65 nM for Akt1, Akt2 and Akt3, respectively.

IC50 & Target: IC50: 5 nM/12 nM/65 nM (Akt1/Akt2/Akt3)[1]

In Vitro: The NPC cell lines CNE-1, CNE-2, HONE-1, and SUNE-1 are treated with increasing doses of MK-2206 (0-10 μM) for 72 and 96 hours, results in dose- and time-dependent inhibition of cell viability. At 72 and 96 hours, the IC50 values of MK-2206 in CNE-1, CNE-2, and HONE-1 cell lines are 3-5 μM, and in SUNE-1, they are less than 1 μM[1]. MK-2206 alone more potently inhibits the cell growth of Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292; IC50s of 5.5, 4.3, and 5.2 μM, respectively) as compared with Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6; IC50s of 13.5, 14.1, 27.0, and 28.6 μM, respectively), with the exception of NCI-H460, which has a PIK3CA E545K mutation (IC50, 3.4 μM)[2].

In Vivo: MK-2206 doses (480 mg/kg once a week and 240 mg/kg three times a week) can inhibit the growth of human CNE-2 xenografts in nude mice. In the two MK-2206 groups, the tumor weights are much lighter than the control group (P<0.01). Temporal body weight reduction is observed after receiving the MK-2206 treatment[1].

Information

CAS No1032350-13-2
FormulaC25H23Cl2N5O
Clinical Informationclinicalinformation
PathwayPI3K/Akt/mTOR
Autophagy
TargetAkt
Autophagy

Specifications

Purity / Grade>98%
SolubilityDMSO : 4.9 mg/mL (10.20 mM; Need ultrasonic and warming); H2O : 3.81 mg/mL (7.93 mM; Need ultrasonic and warming)
Smilessmiles

Misc Information

Observed Molecular Weight480.39
Get valuable resources and offers directly to your email.